Description

nAre you a talented and motivated life-science modelling & simulation scientist with experience in the pharma industry? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBPK/DDI) modelling ? This position offers you this and more exciting work in an innovative and fast-paced environment
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ESQlabs
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nTo help us grow our global PBPK/DDI impact , we are looking forSenior/Principal Scientist Systems Pharmacology PBPK / DDIa to strengthen our multi-disciplinary project teams for the successful completion of client goals.n

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About usn

nWe collaborate with global corporations in the pharma and chemical industry, as well as start-ups in the life-science technology sector and academic and non-profit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized treatment of patients and protect the health of the animal and human life.nn

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nESQlabs has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EU-wide research grants allows us to develop our core technologies continuously.nn

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nAt ESQlabs,

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Rolen

  • nComplement a dedicated high-performing team of scientistsnn

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  • nCollaborate with colleagues on multi-disciplinary teams to implement quantitative clinical pharmacology projects/programs and to provide clinical pharmacology and PBPK/DDI consultation to other company projects/programsnn

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  • nProvide clinical pharmacology and pharmacometric consulting through advanced PBPK/DDI, and exposure-response modeling and simulation using the OSP-Suite (PK-Sim, MoBi, R), or other toolsnn

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  • nSupport clinical pharmacology-related components of clinical study protocols, study conduct, data analysis, and report writing with the support of colleaguesnn

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  • nResponsible for appropriateness of methods, integrity of data used for analysis, and accuracy of resultsnn

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  • nRegularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, and messaging of findingsnn

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  • nPrepare final technical reports, synopses, executive summaries, and other regulatory documentsnn

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  • nEnsure the provision of advanced literature searches for project/program-related informationnn

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  • nProvide sophisticated written interpretation of material and integrate research findings into project/program methodology and resultsnn

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  • nShare findings with internal and external project teams; prepare abstracts, presentations, and publication-ready manuscriptsnn

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  • nProvide mentoring and feedback to junior scientistsnn

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  • nIntegrate knowledge of PBPK and DDI to provide guidance regarding proposed approaches to addressing drug development and regulatory approval challengesnn

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  • nExpand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client meetings, and government meetingsnn

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  • nDevelop and teach at OSP-Suite (PK-Sim, MoBi, R), and other workshops and coursesnn

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  • n5+ years (Principal 10+ years) of applied (pre-)clinical pharmacology experiencenn

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  • n3+ years (Principal 5+ years) of leading projects and programsnn

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  • n3+ years (Principal 5+ years) of experience in regulatory applications of PBPK modeling in pre-clinical and clinical developmentnn

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  • nGood knowledge of regulatory requirements and guidelines for PBPK and DDInn

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  • nStrong experience presenting scientific results to professional audiencesnn

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  • nExtensive experience preparing, submitting, and receiving approval for publications in scientific journalsnn

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  • nMechanistic physiologically based pharmacokinetic modeling and simulation experiencenn

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  • nExpert knowledge in domain-specific modeling software (e.g. PK-Sim® / MoBi®, SimCyp®, or GastroPlus®)nn

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  • nExcellent communication, presentation, and leadership skillsnn

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  • nRelationship-building skills with the ability to work closely with project leaders and team membersnn

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  • nStrong organization skills and ability to handle multiple tasks simultaneouslynn

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  • nWork well handling tight deadlinesnn

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  • nGreat critical-thinking and problem-solving skillsnn

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  • nFluency in English (oral and written), German is a plusnn

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Educationn

  • nPhD, or masters in quantitative sciences (Bioengineering, Applied Math, …) with advanced (pre)clinical pharmacology related training ornn

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  • nPharmD or PhD in pharmacokinetics, clinical pharmacology, or related field with advanced applied mathematics related trainingnn

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Further qualities that will put you in the spotlightn

  • nExperience in (IND/NDA) submissionsnn

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  • nAdvanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)nn

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  • nProficiency in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)nn

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  • nA strong understanding of statisticsnn

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  • nTherapeutic domain knowledge: Diabetes, Oncology, Immunology or Inflammationnn

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· Fully Remotenn

n100% Home Office in the EU (preferred: Germany, Portugal, Spain, France, Netherlands, Belgium, Italy), or the UK. Regular F2F meetings in exciting EU locations. EU WORK VISA required, can be obtainednn

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‘s in store for you
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nThe dynamic team behind ESQlabs unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our open-mindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always willing to broaden our horizons, and love our start-up culture.nn

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nYou will also benefit from:nn

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  • nFlexible work hours and a home office policy that focuses on people and not on numbersnn

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  • nAn attractive remuneration packagenn

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  • nA dedicated budget for education programs and conferences you can attendnn

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  • nA working environment in which your contribution will make a difference, and that allows you to take ownership of projects and processesnn

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  • nResponsibility, autonomy