Senior/Principal Scientist Systems Toxicology (m/f/d) Systems Toxicology · Saterland / Home Off[…]

Are you a highly talented and motivated
d Modelling & Simulation Scienti
ist with experience in the pharma, cosmetics, crop protection, flavoring, or chemistry industry? Do you enjoy driving innovation and setting new boundaries in System Toxicology and Risk Assessment? This position offers you this and more exciting work in an innovative and fast-paced environm
ent. ES
SQlabs is an innovative, internationally acting Contract Research Organization and a global leader in the development and application of the OSPwww.open-systems-pharmacology.orgSuite (). We are a research-focused provider of specialized computational analyses in the life sciences i
ndustry. T
To help us grow our global PBK/QST business , we are lo
ooking for a Senior Scientist Systems Toxic
cology (m/f/d) to strengthen our multi-disciplinary project teams for the successful completion of client goals. We collaborate with global corporations in the pharma and chemical industry, as well as start-ups in the life-science technology sector and academic and non-profit research institutions. We define new standards in pharmacometrics and systems pharmacology and toxicology areas. Our software and model platforms help scientists understand mechanisms of diseases and chemical toxicity to optimize individualized tre
atment of patients and protect the health of the animal and human life. esqLABS has attracted international players as sponsors for the OSP Software development. In addition, funding through national and EU-wide
research grants allows us to develop our core technologies continuous
sly.

This role will engage in activities ranging from consultations on study design and regulatory requirements through the development and evaluation of models, the performance of simulations, and the presentat
ion
of results. Complement a dedicated high-performing
team of scientists Collaborate with colleagues on multi-disciplinary teams to implement quantitative modeling and simulation projects/programs and to provide risk assessment and PBK/QST consultation to other compan
y projects/programs Provide modeling and simulation consulting through advanced PBK, QST, and exposure-response modeling and simulation using the OSP-Suite (PK-Sim, MoBi
, R), or other tools Support risk assessment protocols, study conduct, data analysis, and report writing with the
support of colleagues Responsible for appropriateness of methods, integrity of data used for analysis, a
nd accuracy of results Regularly engage with clients regarding the strategic approach, project execution, presentation of results, regulatory implications, an
d messaging of findings Prepare final technical reports, synopses, executive summaries, and ot
her regulatory documents Ensure the provision of advanced literature searches for project/pr
ogram-related information Provide sophisticated written interpretation of material and integrate research findings into project/progr
am methodology and results Share findings with internal and external project teams; prepare abstracts, presentations, and pu
blication-ready manuscripts Provide mentoring and f
eedback to junior scientists Integrate knowledge of PBK and QST to provide guidance regarding proposed approaches to address risk assessment and r
egulatory approval challenges Expand scientific expertise through attendance and presentation at international, national, and regional scientific conferences, client mee
tings, and government meetings Develop and teach at OSP-Suite (PK-Sim, MoBi, R),
and other workshops and cour
rses

Required Skills & Experience 5+ years (Principa
l 10+ years) of applied toxicology 3+ years (Principal 5+ year
s) of leading projects and programs 3+ years (Principal 5+ years) of experience in reg
ulatory applications of PBK modeling Good knowledge of regulatory requir
ements and guidelines for PBK and QST Strong experience presenting scient
ific results to professional audiences Extensive experience preparing, submitting, and receiving approval
for publications in scientific journals Mechanistic physiologically based ki
netic modeling and simulation experience Expert knowledge in domain-specific modeling software (e.g. PK-Sim
/MoBi, SimCyp, or GastroPlus or TK-plate) Excellent communic
ation, presentation, and leadership skills Relationship-building skills with the ability to work cl
osely with project leaders and team members Strong organization skills and abi
lity to handle multiple tasks simu
ltaneously Work well handling tight deadlines Grea
t critical-thinking and problem-solving skills Fluency
in Englis
sh (oral and written), German is a plus Education PhD, or masters in quantitative sciences (Bioengineering, Applied Ma
th, …) with advanced toxicology related training Or PharmD or PhD in pharmacology, toxicology, or related field
with advanced applied mathematics related training Further Qualities That Will Put You in the Spotlight Experience in regulatory submissions Advanced expertise in kinetic
s modeling software (e.g. NONMEM, Monolix, or IQRtools) Proficiency in a scripting language for m
odeling and simulation (ideally R, a
lternatively MATLAB) A strong understanding of statistics Strategic domain kno
wledge: Drug development, Crop p
rotection, Flavoring, e
etc. Published peer-reviewed articles

The dynamic team behind esqLABS unites people with different backgrounds, spanning disciplines like pharmaceutical sciences, physics, bioinformatics, mathematics, data science, and software engineering. Our trust in each other, our open-mindedness, and our constant quest for excellence and innovation unite us. We value flat hierarchies, where everyone can contribute ideas and expertise to develop the best product. We are passionate, always w
illing to broaden our horiz
ons, and love our start-up culture. You will also benefit from: Flexible work hours an
d a home office policy that focuse
s on people and not on numbers An attractive remuneration package A dedi
cated budget for education programs and conferences you can attend A working environment in which your contribution will make a differen
ce, and that allows you to take ownership of projects and proce
sses Res
sponsibility, autonomy, participation, and career perspective For more information about our culture,
values and benefits visit our Unique career opportunities – esqLABS
S GmbH . At esqLABS, we are committed to diverse backgrounds and experiences. #J-18808-Ljbffr